منابع مشابه
Sequence-Disorder Effects on DNA Entropic Elasticity
DNA stretching experiments are usually interpreted using the wormlike chain model; the parameter A appearing in the model is then interpreted as giving the elastic bend stiffness of the double helix. Actually, however, the value of A obtained by this method is a combination of bend stiffness and intrinsic bend effects reflecting sequence information, just as at zero stretching force. This obser...
متن کاملSequence Effects on DNA Entropic Elasticity
DNA stretching experiments are usually interpreted using the worm-like chain model; the persistence length A appearing in the model is then interpreted as the elastic stiffness of the double helix. In fact the persistence length obtained by this method is a combination of bend stiffness and intrinsic bend effects reflecting sequence information, just as at zero stretching force. This observatio...
متن کاملEntropic Elasticity of DNA with a Permanent Kink
Many proteins interact with and deform double-stranded DNA in cells. Single-molecule experiments have studied the elasticity of DNA with helix-deforming proteins, including proteins that bend DNA. These experiments increase the need for theories of DNA elasticity which include helix-deforming proteins. Previous theoretical work on bent DNA has examined a long DNA molecule with many nonspecifica...
متن کاملTorsional directed walks, entropic elasticity, and DNA twist stiffness.
DNA and other biopolymers differ from classical polymers because of their torsional stiffness. This property changes the statistical character of their conformations under tension from a classical random walk to a problem we call the "torsional directed walk." Motivated by a recent experiment on single lambda-DNA molecules [Strick, T. R., Allemand, J.-F., Bensimon, D., Bensimon, A. & Croquette,...
متن کاملDNA entropic elasticity for short molecules attached to beads
Single-molecule experiments in which force is applied to DNA or RNAmolecules have enabled important discoveries of nucleic acid properties and nucleic acid-enzyme interactions. These experiments rely on a model of the polymer force-extension behavior to calibrate the experiments; typically the experiments use the worm-like chain (WLC) theory for double-stranded DNA and RNA. This theory agrees w...
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ژورنال
عنوان ژورنال: Science
سال: 1994
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.8079175